F2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: effects of vitamin E

We have concurrently investigated oxidant stress, glucose tolerance and glucose-stimulated insulin responses in the obese Zucker rat, a widely used model of insulin resistance. The plasma level of the lipid peroxidation product 8-epi-prostaglandin F2alpha, a sensitive in vivo marker of oxidant stres...

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Bibliographic Details
Published in:European journal of pharmacology 1999-07, Vol.377 (1), p.89-92
Main Authors: LAIGHT, D. W, DESAI, K. M, GOPAUL, N. K, ÄNGGARD, E. E, CARRIER, M. J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - drug effects
Blood Glucose - metabolism
Body Weight - drug effects
Dietary Supplements
Dinoprost - analogs & derivatives
Dinoprost - blood
General and cellular metabolism. Vitamins
Hyperglycemia - blood
Hyperglycemia - prevention & control
Hyperinsulinism - blood
Hyperinsulinism - prevention & control
Insulin - blood
Insulin Resistance
Male
Medical sciences
Obesity - blood
Obesity - physiopathology
Oxidative Stress - drug effects
Oxidative Stress - physiology
Pharmacology. Drug treatments
Rats
Rats, Zucker
Vitamin E - pharmacology
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Summary:We have concurrently investigated oxidant stress, glucose tolerance and glucose-stimulated insulin responses in the obese Zucker rat, a widely used model of insulin resistance. The plasma level of the lipid peroxidation product 8-epi-prostaglandin F2alpha, a sensitive in vivo marker of oxidant stress, was elevated approximately 5-fold in 13-week old obese relative to age-matched, insulin-sensitive lean Zucker rats. Supplementation of the diet with vitamin E (as (+)-alpha-tocopherol acetate, 0.5% w/w) for 4 weeks, reduced plasma 8-epi-prostaglandin F2alpha and concomitantly reversed glucose-stimulated hyperinsulinaemia in the obese Zucker rat without worsening glucose tolerance. We therefore provide evidence of oxidant stress, measured as elevated plasma 8-epi-prostaglandin F2alpha, for the first time in the obese Zucker rat which now provides a rationale for the beneficial effects of antioxidants on insulin action previously reported in this model of insulin resistance.
ISSN:0014-2999
1879-0712
DOI:10.1016/s0014-2999(99)00407-0