Factor XIII insufficiency in a patient with severe psoriasis vulgaris, arthritis, and infirmity

Factor XIII (FXIII) links soluble fibrin monomers and collagen fibres to stable fibrin connections. Deficiency of FXIII, caused by dyspoiesis or increased consumption, results in a bleeding tendency and wound healing complications. Although the decrease of FXIII and successful replacement in patient...

Full description

Saved in:
Bibliographic Details
Published in:Clinical rheumatology 1998-01, Vol.17 (4), p.346-348
Main Authors: Heinle, K, Adam, O, Rauh, G
Format: Article
Language:English
Subjects:
Adult
Arthritis - complications
Autoimmune diseases
Blood Coagulation
Factor XIII - metabolism
Factor XIII Deficiency - blood
Factor XIII Deficiency - complications
Follow-Up Studies
Hemorrhage - blood
Hemorrhage - complications
Humans
Male
Psoriasis - complications
Wasting Syndrome - complications
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Factor XIII (FXIII) links soluble fibrin monomers and collagen fibres to stable fibrin connections. Deficiency of FXIII, caused by dyspoiesis or increased consumption, results in a bleeding tendency and wound healing complications. Although the decrease of FXIII and successful replacement in patients with wound healing complications after surgery have been described by several authors, it is rarely considered that patients with autoimmune diseases, bleeding or healing complications may suffer from FXIII deficiency. We report a patient with severe psoriasis vulgaris generalisata with large, painful erythemas, bleeding tendency, joint contractions and infirmity, whose FXIII activity was 19%. After successful replacement the bleeding tendency vanished, and a marked improvement of skin and joint mobility allowed mobilisation and administration of physical therapy, whereby some independence and mobility were restored to the patient.
ISSN:0770-3198
1434-9949
DOI:10.1007/BF01451020