Atherosclerosis seems not to be associated with hyperinsulinaemia in patients with familial hypercholesterolaemia

Objective. To study the relationship between hyperinsulinaemia, insulin resistance, leptin and atherosclerosis in subjects with familial hypercholesterolaemia (FH). Design. Case‐control cross‐sectional study. Setting. Lipid clinic, Johannesburg Hospital, South Africa. Subjects and methods. Fasting s...

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Bibliographic Details
Published in:Journal of internal medicine 1999-07, Vol.246 (1), p.75-80
Main Authors: Raal, F. J., Panz, V. R., Pilcher, G. J., Joffe, B. I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arteriosclerosis - blood
Arteriosclerosis - complications
atherosclerosis
Biological and medical sciences
Blood Glucose - metabolism
Body Mass Index
Coronary Disease - complications
Disorders of blood lipids. Hyperlipoproteinemia
familial hypercholesterolaemia
Female
Heterozygote
Homozygote
Humans
Hyperinsulinism - blood
Hyperinsulinism - complications
Hyperlipoproteinemia Type II - blood
Hyperlipoproteinemia Type II - complications
insulin
Insulin - blood
Insulin Resistance
Leptin
Lipids - blood
Male
Medical sciences
Metabolic diseases
Proteins - metabolism
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Summary:Objective. To study the relationship between hyperinsulinaemia, insulin resistance, leptin and atherosclerosis in subjects with familial hypercholesterolaemia (FH). Design. Case‐control cross‐sectional study. Setting. Lipid clinic, Johannesburg Hospital, South Africa. Subjects and methods. Fasting serum lipid, glucose, insulin and leptin levels were measured in 24 homozygous FH subjects; 20 FH heterozygotes without coronary artery disease (CAD); 22 heterozygotes with documented CAD; and 20 healthy normocholesterolaemic subjects. Insulin resistance was calculated using the homeostasis model assessment (HOMA) formula. Results. Mean glucose and insulin levels were similar in all 4 groups. There was no significant difference in calculated insulin resistance between any of the groups. There was also no relationship between the degree of insulin resistance and total or LDL‐cholesterol levels. Using Spearman’s correlation coefficient (Rs) calculated insulin resistance correlated with triglyceride (Rs = 0.27; P 
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.1999.00508.x