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Solid phase synthesis of quinolones

Solid phase syntheses of ethyl 6-carboxyquinol-4(1H)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated. Synthesis of quinolones ( 5,7a-d) has been carri...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-07, Vol.9 (14), p.1885-1888
Main Authors: Srivastava, Sanjay K., Haq, W., Murthy, P.K., Chauhan, P.M.S.
Format: Article
Language:English
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Summary:Solid phase syntheses of ethyl 6-carboxyquinol-4(1H)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated. Synthesis of quinolones ( 5,7a-d) has been carried out on solid support and their in vitro antifilarial activity against B. malayi have been delineated.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00326-1