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Solid phase synthesis of quinolones
Solid phase syntheses of ethyl 6-carboxyquinol-4(1H)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated. Synthesis of quinolones ( 5,7a-d) has been carri...
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Published in: | Bioorganic & medicinal chemistry letters 1999-07, Vol.9 (14), p.1885-1888 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Solid phase syntheses of ethyl 6-carboxyquinol-4(1H)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides
7a-d have been described. Antifilarial in vitro activities of
5,7a-d against Brugia malayi have also been delineated.
Synthesis of quinolones (
5,7a-d) has been carried out on solid support and their
in vitro antifilarial activity against
B. malayi have been delineated. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(99)00326-1 |