Manometry of the upper intestinal tract in patients with systemic sclerosis: A prospective study

• Published in: Arthritis and rheumatism 1998-10, Vol.41 (10), p.1874-1883
• Main Authors: Marie, Isabelle, Levesque, Hervé, Ducrotté, Philippe, Denis, Philippe, Benichou, Jacques, Hellot, Marie‐France, Cailleux, Nicole, Le Loët, Xavier, Joly, Pascal, Lauret, Philippe, Courtois, Hubert
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Esophageal Motility Disorders - complications; Female; Humans; Intestinal Diseases - complications; Intestinal Diseases - epidemiology; Intestine, Small; Male; Manometry; Medical sciences; Middle Aged; Prevalence; Prospective Studies; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Scleroderma, Systemic - complications
• ISSN: 0004-3591; 1529-0131
• DOI: 10.1002/1529-0131(199810)41:10<1874::AID-ART21>3.0.CO;2-T

Objective To assess both the prevalence and the characteristics of motor disorders of the small bowel in patients with systemic sclerosis (SSc) and to investigate for an association between clinical manifestations in the upper intestinal tract, capillaroscopic features, esophageal motor impairment, and manometric evidence of motor disturbances. Methods Fasting and postprandial motor activity of the upper intestinal tract was studied in 17 consecutive patients with SSc (6 with and 11 without clinical manifestations of small bowel involvement) and 17 age‐and sex‐matched healthy control subjects. Results The prevalence of manometric evidence of intestinal involvement was as high as 88% in the SSc patients; normal motor activity was present in only 2 patients. The median values for duodenal and jejunal interdigestive phase III migrating motor complex duration, amplitude, and velocity and the postprandial motility index were therefore lower in SSc patients compared with controls. Our manometric findings indicated that there are both neuropathic and myopathic stages of upper intestinal tract dysfunction in SSc. Furthermore, no association could be found between the severity of the intestinal manometric abnormalities and clinical presentation, SSc subsets, disease score, capillaroscopic findings, or esophageal manometric impairment. Conclusion We suggest that manometry of the upper intestinal tract may be useful in SSc patients with clinical manifestations in the small bowel (i.e., malabsorption syndrome or pseudoobstruction) in that it can be used to accurately evaluate both the nature and the severity of motor disturbances. Furthermore, this procedure can be used to assist in the selection of patients who may require octreotide therapy.