Molecular metastases in stage I pancreatic cancer: Improved survival with adjuvant chemoradiation

Background: Reports of improved survival rates for patients with resected adenocarcinoma of the pancreas coincide with the adoption of adjuvant chemoradiation protocols. The impact of nodal micrometastases demonstrated by molecular assays and adjuvant therapy on survival of patients with stage I pan...

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Bibliographic Details
Published in:Surgery 1998-10, Vol.124 (4), p.663-669
Main Authors: Demeure, Michael J., Doffek, Kara M., Komorowski, Richard A., Redlich, Philip N., Zhu, Yong-ran, Erickson, Beth A., Ritch, Paul S., Pitt, Henry A., Wilson, Stuart D.
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Aged
Chemotherapy, Adjuvant
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - therapy
Point Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Proto-Oncogene Proteins p21(ras) - genetics
Radiotherapy, Adjuvant
Retrospective Studies
Survival Rate
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Summary:Background: Reports of improved survival rates for patients with resected adenocarcinoma of the pancreas coincide with the adoption of adjuvant chemoradiation protocols. The impact of nodal micrometastases demonstrated by molecular assays and adjuvant therapy on survival of patients with stage I pancreatic cancer has not been adequately assessed. Methods: A retrospective analysis of postoperative chemoradiation on survival in 61 patients undergoing resection of pancreatic adenocarcinomas from 1984 to 1997 was performed. Archival tumors and regional nodes from 25 patients with stage I cancers were tested for a Kiras oncogene mutation using polymerase chain reaction and analysis for restriction fragment length polymorphisms (PCR/RFLP). Results: Adjuvant chemoradiation was associated with improved survival for stage I (P
ISSN:0039-6060
1532-7361
DOI:10.1067/msy.1998.91487