Clusterin in Bovine Spongiform Encephalopathy (BSE)

Clusterin mRNA, detected in increased quantities in the cervical spinal cord of cattle with bovine spongiform encephalopathy (BSE), was localized mainly in the neuroglia (including astrocytes) of the lateral and ventral areas of white matter. Axonal degeneration was also observed in these areas. The...

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Bibliographic Details
Published in:Journal of comparative pathology 1999-08, Vol.121 (2), p.159-171
Main Authors: McHattie, S., Wells, G.A.H., Bee, J., Edington, N.
Format: Article
Language:English
Subjects:
animal proteins
Animals
Blotting, Northern
bovine spongiform encephalopathy
Cattle
Cell Count
central nervous system
Central Nervous System - metabolism
Central Nervous System - pathology
Clusterin
Encephalopathy, Bovine Spongiform - metabolism
Encephalopathy, Bovine Spongiform - pathology
Glycoproteins - metabolism
Immunohistochemistry
In Situ Hybridization
messenger RNA
Molecular Chaperones
Nerve Tissue Proteins - metabolism
Neuropil - metabolism
prions
Prions - metabolism
RNA, Messenger - metabolism
Spinal Cord - metabolism
Spinal Cord - pathology
Thalamus - metabolism
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Description
Summary:Clusterin mRNA, detected in increased quantities in the cervical spinal cord of cattle with bovine spongiform encephalopathy (BSE), was localized mainly in the neuroglia (including astrocytes) of the lateral and ventral areas of white matter. Axonal degeneration was also observed in these areas. The dorsal horns of the spinal cord in which BSE prion protein (PrPBSE) was deposited did not exhibit strong clusterin “up-regulation” but showed increased clusterin immunolabelling with a punctate distribution in the neuropil. Labelling of adjacent sections of the grey matter in BSE-affected spinal cord and thalamus demonstrated that the clusterin was deposited in association with extracellular PrPBSE.
ISSN:0021-9975
1532-3129
DOI:10.1053/jcpa.1999.0313