Enhanced Responses to Mycobacterium tuberculosis Antigens by Human Alveolar Lymphocytes during Active Pulmonary Tuberculosis

Responses to mycobacterial and nonmycobacterial antigens were examined in bronchoalveolar cells (BAC) and peripheral blood mononuclear cells (PBMC) from patients with active pulmonary tuberculosis (n = 16) and healthy subjects (n = 23). DNA synthesis in BAC (but not PBMC) from tuberculosis patients...

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Published in:The Journal of infectious diseases 1998-11, Vol.178 (5), p.1434-1445
Main Authors: Schwander, Stephan K., Torres, Martha, Sada, Eduardo, Carranza, Claudia, Ramos, Esther, Tary-Lehmann, Magdalena, Wallis, Robert S., Sierra, Juan, Rich, Elizabeth A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS/HIV
Antigens
Antigens, Bacterial - immunology
Bacterial diseases
Biological and medical sciences
Blood
Blood cells
Cell Compartmentation
Enzyme-Linked Immunosorbent Assay
Human bacterial diseases
Humans
Infectious diseases
Lipopolysaccharides - immunology
Lungs
Lymphocytes
Lymphocytes - immunology
Macrophages, Alveolar - immunology
Medical sciences
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Pulmonary Alveoli - cytology
Pulmonary Alveoli - immunology
Pulmonary tuberculosis
T lymphocytes
T-Lymphocytes - immunology
Th1 Cells - immunology
Th1 Cells - metabolism
Tuberculin
Tuberculin - immunology
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Pulmonary - immunology
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container_issue 5
container_start_page 1434
container_title The Journal of infectious diseases
container_volume 178
creator Schwander, Stephan K.
Torres, Martha
Sada, Eduardo
Carranza, Claudia
Ramos, Esther
Tary-Lehmann, Magdalena
Wallis, Robert S.
Sierra, Juan
Rich, Elizabeth A.
description Responses to mycobacterial and nonmycobacterial antigens were examined in bronchoalveolar cells (BAC) and peripheral blood mononuclear cells (PBMC) from patients with active pulmonary tuberculosis (n = 16) and healthy subjects (n = 23). DNA synthesis in BAC (but not PBMC) from tuberculosis patients was significantly increased in response to the mycobacterial antigens purified protein derivative (PPD), antigen 85, and mannose-capped lipoarabinomannan but not to nonmycobacterial antigens. The response to PPD was also increased in enriched alveolar lymphocytes from tuberculosis patients (P < .05). The frequency of interferon-γ but not interleukin-4- or -10—producing cells by ELISAspot was increased in PPD-stimulated BAC from patients with tuberculosis (P < .05). Accessory function of alveolar macrophages for T lymphocyte responses was similar and suppressive activity was variably decreased in tuberculosis patients. Thus, there is compartmentalization of mycobacterial antigen-specific lymphocytes to the lungs during active tuberculosis that on challenge produce a Th1-type cytokine host response.
doi_str_mv 10.1086/314454
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DNA synthesis in BAC (but not PBMC) from tuberculosis patients was significantly increased in response to the mycobacterial antigens purified protein derivative (PPD), antigen 85, and mannose-capped lipoarabinomannan but not to nonmycobacterial antigens. The response to PPD was also increased in enriched alveolar lymphocytes from tuberculosis patients (P &lt; .05). The frequency of interferon-γ but not interleukin-4- or -10—producing cells by ELISAspot was increased in PPD-stimulated BAC from patients with tuberculosis (P &lt; .05). Accessory function of alveolar macrophages for T lymphocyte responses was similar and suppressive activity was variably decreased in tuberculosis patients. 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ispartof The Journal of infectious diseases, 1998-11, Vol.178 (5), p.1434-1445
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source Oxford Journals Online; JSTOR Archival Journals
subjects Adolescent
Adult
AIDS/HIV
Antigens
Antigens, Bacterial - immunology
Bacterial diseases
Biological and medical sciences
Blood
Blood cells
Cell Compartmentation
Enzyme-Linked Immunosorbent Assay
Human bacterial diseases
Humans
Infectious diseases
Lipopolysaccharides - immunology
Lungs
Lymphocytes
Lymphocytes - immunology
Macrophages, Alveolar - immunology
Medical sciences
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Pulmonary Alveoli - cytology
Pulmonary Alveoli - immunology
Pulmonary tuberculosis
T lymphocytes
T-Lymphocytes - immunology
Th1 Cells - immunology
Th1 Cells - metabolism
Tuberculin
Tuberculin - immunology
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Pulmonary - immunology
title Enhanced Responses to Mycobacterium tuberculosis Antigens by Human Alveolar Lymphocytes during Active Pulmonary Tuberculosis
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