Effects of surfactants on glucosyltransferase production and in vitro sucrose-dependent colonization by Streptococcus mutans

The presence of Tween 80 in media was associated with a significant increase in three glucosyltransferases (GTFs) (I, SI and S), especially GTF-I, produced by Streptococcus mutans strain PS14, indicating that the surfactant is a major cause of the enhanced GTF production observed in cultures in M4 m...

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Bibliographic Details
Published in:Archives of oral biology 1998-09, Vol.43 (9), p.735-740
Main Authors: Tomita, Yukihide, Watanabe, Tamae, Takeuchi, Takeo, Nanbu, Akio, Shinozaki, Noriko, Ikemi, Takuji, Fukushima, Kazuo
Format: Article
Language:English
Subjects:
Bacterial Adhesion - drug effects
Dental Plaque - metabolism
Dental Plaque - microbiology
Dentistry
Glucans - biosynthesis
glucosyltransferase production
Glucosyltransferases - drug effects
Glucosyltransferases - metabolism
Humans
Octoxynol - pharmacology
Phosphatidylcholines - pharmacology
plaque formation
Polysaccharides, Bacterial - biosynthesis
Polysorbates - pharmacology
Solubility
Streptococcus mutans
Streptococcus mutans - classification
Streptococcus mutans - drug effects
Streptococcus mutans - enzymology
Streptococcus mutans - metabolism
Sucrose - metabolism
Surface-Active Agents - pharmacology
surfactants
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Summary:The presence of Tween 80 in media was associated with a significant increase in three glucosyltransferases (GTFs) (I, SI and S), especially GTF-I, produced by Streptococcus mutans strain PS14, indicating that the surfactant is a major cause of the enhanced GTF production observed in cultures in M4 medium. Lecithin and Tween 20 also enhanced GTF-I production, while Triton X-100 depressed it. At a lot concentration of 0.00125%, Tween 80 enhanced markedly only GTF-I production and its effect reached maximum at a concentration of 0.0025%. Water-insoluble glucan synthesis and artificial plaque formation (in vitro sucrose-dependent colonization) by PS14 were significantly enhanced by the addition of Tween 80 at concentrations over 0.00125%. These results suggest that surfactants might vary the cariogenic potential of Strep. mutans even at low concentrations.
ISSN:0003-9969
1879-1506
DOI:10.1016/S0003-9969(98)00065-X