Impaired antibody response after immunization of HIV-infected individuals with the polysaccharide vaccine against Salmonella typhi (Typhim-Vi®)

Infections with Salmonella species, including Salmonella typhi, are more frequently observed in HIV-infected individuals than in healthy individuals. HIV-infected individuals were vaccinated with polysaccharide vaccine against Salmonella typhi (Typhim-Vi®) which is assumed to be a T-cell-independent...

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Bibliographic Details
Published in:Vaccine 1999-08, Vol.17 (23), p.2941-2945
Main Authors: Kroon, Frank P., van Dissel, Jaap T., Ravensbergen, Elisabeth, Nibbering, Peter H., van Furth, Ralph
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Antibodies, Bacterial - biosynthesis
Bacteriology
Biological and medical sciences
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
Epidemiology. Vaccinations
Female
Fundamental and applied biological sciences. Psychology
General aspects
HIV Infections - immunology
HIV-1 - genetics
HIV-infection
Human immunodeficiency virus
Humans
Infectious diseases
Lymphocyte Activation - immunology
Male
Medical sciences
Microbiology
Middle Aged
Polysaccharide salmonella Vi-antigen
Polysaccharides, Bacterial - adverse effects
Polysaccharides, Bacterial - immunology
RNA, Viral - metabolism
Salmonella typhi
Salmonella typhi - immunology
Typhoid Fever - prevention & control
Typhoid-Paratyphoid Vaccines - adverse effects
Typhoid-Paratyphoid Vaccines - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Summary:Infections with Salmonella species, including Salmonella typhi, are more frequently observed in HIV-infected individuals than in healthy individuals. HIV-infected individuals were vaccinated with polysaccharide vaccine against Salmonella typhi (Typhim-Vi®) which is assumed to be a T-cell-independent antigen. We found that the antibody response in patients with
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00167-X