Biological Properties of Salmon Calcitonin IV

In this study we characterized the biological activity of the recently identified salmon calcitonin (sCT) IV, in order to evaluate its potential therapeutic value. In the rat bioassay, sCT IV exhibited a 30% higher hypocalcemic activity than sCT I. The capacity of the molecule to inhibit bone resorp...

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Bibliographic Details
Published in:Journal of bone and mineral research 1999-08, Vol.14 (8), p.1425-1431
Main Authors: Schecroun, Nadia, Pidoux, Elisabeth, Horne, William C., Hernandez‐Lagunas, Laura, Baron, Roland, Cressent, Michele
Format: Article
Language:English
Subjects:
Animals
Antigens - immunology
Biological and medical sciences
Biological Assay
Bone Resorption - physiopathology
Calcitonin - immunology
Calcitonin - physiology
Cross Reactions
Cyclic AMP - biosynthesis
Female
Hormones. Endocrine system
Logistic Models
Male
Medical sciences
Pharmacology. Drug treatments
Pregnancy
Protein Isoforms - physiology
Rabbits
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors, Calcitonin - physiology
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Summary:In this study we characterized the biological activity of the recently identified salmon calcitonin (sCT) IV, in order to evaluate its potential therapeutic value. In the rat bioassay, sCT IV exhibited a 30% higher hypocalcemic activity than sCT I. The capacity of the molecule to inhibit bone resorption was assessed in vitro by the bone resorbing assay and the pit assay. An inhibitory effect, similar to that of sCT I, was observed in both assays. The interaction of sCT IV with the rabbit CT receptor was also studied. The affinity of sCT IV for the receptor was similar to that of sCT I, as was the potency for stimulating cAMP production. The antigenicity of the two molecules was not identical. Thus, this new CT could represent a useful novel therapeutic agent for the treatment of bone disorders.
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.1999.14.8.1425