Cloning of a second proopiomelanocortin cDNA from the pituitary of the sturgeon, Acipenser transmontanus

A recent study on the pituitary of the sturgeon, Acipenser transmontanus, resulted in the cloning of a cDNA that codes for the prohormone, proopiomelanocortin (POMC). This cDNA is designated sturgeon POMC A. Subsequent analysis of the sturgeon pituitary uncovered a second distinct POMC cDNA (sturgeo...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1999-01, Vol.20 (4), p.431-436
Main Authors: Alrubaian, Jasem, Danielson, Phillip, Fitzpatrick, Martin, Schreck, Carl, Dores, Robert M
Format: Article
Language:English
Subjects:
Acipenser transmontanus
Amino Acid Sequence
Animals
Base Sequence
Brackish
Cloning, Molecular
DNA, Complementary - genetics
Fishes - genetics
Freshwater
Gene Duplication
Marine
Molecular Sequence Data
Open Reading Frames
Pituitary Gland - chemistry
Point Mutation
Pro-Opiomelanocortin - genetics
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
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Summary:A recent study on the pituitary of the sturgeon, Acipenser transmontanus, resulted in the cloning of a cDNA that codes for the prohormone, proopiomelanocortin (POMC). This cDNA is designated sturgeon POMC A. Subsequent analysis of the sturgeon pituitary uncovered a second distinct POMC cDNA (sturgeon POMC B). In both sturgeon POMC cDNAs the open reading frame is 795 nucleotides in length. However, the two sturgeon POMC cDNAs differ at 26 amino acid positions in the opening frame. In addition, the 2 forms of POMC differ at 45 nucleotide positions within the open reading frame. The number and types of point mutations are compared in the 2 sturgeons POMC cDNAs, and the origin of the two POMC genes is discussed.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(99)00021-2