Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-Cholesterol levels in overweight men

• Published in: Metabolism, clinical and experimental clinical and experimental, 1999-08, Vol.48 (8), p.943-945
• Main Authors: HAGBERG, J. M, FERRELL, R. E, KATZEL, L. I, DENGEL, D. R, SORKIN, J. D, GOLDBERG, A. P
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Aged, 80 and over; Apolipoproteins E - blood; Apolipoproteins E - genetics; Biological and medical sciences; Body Weight; Cholesterol, HDL - blood; Exercise; Fundamental and applied biological sciences. Psychology; Humans; Lipids. Glycolipids; Lipoproteins, HDL - blood; Lipoproteins, HDL - genetics; Male; Metabolisms and neurohumoral controls; Middle Aged; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/s0026-0495(99)90185-3

We determined if the apolipoprotein E (APO E) genotype affects the exercise training-induced increase in plasma high-density lipoprotein cholesterol (HDL-C) and HDL2-C. Sedentary overweight men on an American Heart Association (AHA) step I diet had plasma lipoprotein-lipids measured before and after 9 months of endurance exercise training. APO E2 (n = 6), E3 (n = 33), and E4 (n = 12) groups were similar at baseline in terms of age, body weight and composition, and plasma lipoprotein-lipid profiles. APO E2 men had a larger increase in plasma HDL-C and HDL2-C with exercise training than APO E3 and E4 men (HDL-C, 8 +/- 4 v 3 +/- 1 v 2 +/- 1 mg/dL; HDL2-C, 5 +/- 3 v 1 +/- 1 v -1 +/- 1 mg/dL; mean +/- SE, all P < .01). After adjusting for body weight changes, the increases in plasma HDL-C and HDL2-C remained greater in APO E2 versus E3 and E4 men (all P < .03). These results indicate that APO E2 men may have greater plasma HDL-C and HDL2-C increases with endurance exercise training.