Nonenzymatic antioxidants of blood in multiple sclerosis

Free radical action has been suggested as a causal factor in multiple sclerosis. We investigated the plasma level of lipid peroxides expressed in terms of malone dialdehyde and changes in blood nonenzymatic antioxidants (glutathione, alpha-tocopherol, retinol, plasma sulfhydryl groups, and uric acid...

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Bibliographic Details
Published in:Journal of neurology 1999-07, Vol.246 (7), p.533-539
Main Authors: KARG, E, KLIVENYI, P, NEMETH, I, BENCSIK, K, PINTER, S, VECSEI, L
Format: Article
Language:English
Subjects:
Adult
Antioxidants - analysis
Antioxidants - pharmacology
Biological and medical sciences
Female
Free Radicals
Glutathione - blood
Humans
Interferon-beta - therapeutic use
Lipid Peroxides - blood
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Multiple Sclerosis - blood
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
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Summary:Free radical action has been suggested as a causal factor in multiple sclerosis. We investigated the plasma level of lipid peroxides expressed in terms of malone dialdehyde and changes in blood nonenzymatic antioxidants (glutathione, alpha-tocopherol, retinol, plasma sulfhydryl groups, and uric acid) in multiple sclerosis patients with exacerbation or in remission, including a group treated with beta-interferon. The malone dialdehyde level was increased by 38% (n.s.) during exacerbations. The blood concentration of oxidized glutathione was likewise elevated (P
ISSN:0340-5354
1432-1459
DOI:10.1007/s004150050399