Shift from Fetal to Adult Hemoglobin Production in a Preterm Infant After Exchange Transfusion: A Quantitative Approach

• Published in: Pediatric hematology and oncology 1998-09, Vol.15 (5), p.431-435
• Main Authors: Refsum, Harald E., Bechensteen, Anne-Grete, Md, Rolf Lindemann
• Format: Article
• Language: English
• Subjects: Anemia, Neonatal - blood; Anemia, Neonatal - therapy; Biological and medical sciences; Diseases of mother, fetus and pregnancy; Exchange Transfusion, Whole Blood; Fetal Hemoglobin - biosynthesis; Gestational Age; Gynecology. Andrology. Obstetrics; Hemoglobin A - biosynthesis; Humans; Infant, Newborn; Medical sciences; Pregnancy. Fetus. Placenta
• ISSN: 0888-0018; 1521-0669
• DOI: 10.3109/08880019809016572

To evaluate the quantitative aspects of the shift in production from fetal hemoglobin (HbF) to adult hemoglobin (HbA), the HbF and HbA mass were estimated in a preterm infant (gestational age 29 weeks) for 22 weeks after an exchange transfusion the second day of life, leading to an initial HbA % of 100. Up until the estimated time of delivery, the HbA mass declined continuously, at a rate corresponding to a survival time of the transfused HbA erythrocytes of 100 days, and the rise in total hemoglobin mass could be ascribed solely to a rise in the HbF mass. HbF% maximum was reached 3 weeks before HbF mass maximum, and, thus, the HbF% and HbA % time courses gave no basis for evaluation of the production/destruction balance of HbF and HbA erythrocytes. The applied quantitative approach seems to be a useful additional procedure for evaluating the switch from HbF to HbA production and for estimating HbA erythrocyte survival time in preterm infants.