Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina

A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylprol...

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Bibliographic Details
Published in:Microbiology (Society for General Microbiology) 1999-08, Vol.145 (8), p.1919-1926
Main Authors: Strobel, G.A, Miller, V, Martinez-Miller, C, Condron, M.M, Teplow, D.B, Hess, W.M
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
antifungal properties
Ascomycota - growth & development
Ascomycota - isolation & purification
Ascomycota - metabolism
Biological and medical sciences
Botrytis cinerea
Candida albicans
Chromatography, Thin Layer
Cryptosporiopsis quercina
Culture Media
endophytes
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Microbial Sensitivity Tests
Mitosporic Fungi - drug effects
pathogens
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
plant pathogenic fungi
Sclerotinia sclerotiorum
Trichophyton mentagrophytes
Trichophyton rubrum
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Description
Summary:A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known antimycotics, the echinocandins and pneumocandins, which are produced by such fungi as Zalerion arboricola, Pezicula spp. and Aspergillus spp. Cryptocandin has minimal inhibitory concentration values of 0.03-0.07 microgram/ml against isolates of Candida albicans, Trichophyton mentagrophytes and Trichophyton rubrum. Cryptocandin is also active against a number of plant-pathogenic fungi including Sclerotinia sclerotiorum and Botrytis cinerea.
ISSN:1350-0872
1465-2080
DOI:10.1099/13500872-145-8-1919