Development of resistance to beta-lactams and other antibiotics of pneumococci isolated from acute otitis media in France: statement of the National Reference Center 1995-1996

During 1995 and 1996, 393 and 566 strains of Streptococcus pneumoniae, isolated from acute otitis media, were respectively sent to the National Reference Center for Pneumococci by its corresponding centers. The resistance rates for 1995 and 1996 were respectively: for penicillin: 65.4 and 70.3% (18....

Full description

Saved in:
Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 1998-09, Vol.5 (9), p.982-987
Main Authors: Geslin, P, Fremaux, A, Sissia, G, Spicq, C, Georges, S
Format: Article
Language:fre
Subjects:
Acute Disease
Amoxicillin - pharmacology
beta-Lactam Resistance
beta-Lactams - pharmacology
Cefpodoxime
Ceftizoxime - analogs & derivatives
Ceftizoxime - pharmacology
Cefuroxime - pharmacology
Erythromycin - pharmacology
Erythromycin - therapeutic use
France
Humans
Microbial Sensitivity Tests
Otitis Media - drug therapy
Otitis Media - microbiology
Penicillin Resistance
Penicillins - pharmacology
Pneumococcal Infections - drug therapy
Pneumococcal Infections - microbiology
Serotyping
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - isolation & purification
Tetracycline - pharmacology
Tetracycline - therapeutic use
Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During 1995 and 1996, 393 and 566 strains of Streptococcus pneumoniae, isolated from acute otitis media, were respectively sent to the National Reference Center for Pneumococci by its corresponding centers. The resistance rates for 1995 and 1996 were respectively: for penicillin: 65.4 and 70.3% (18.6 and 24.9% of intermediately resistant strains, 46.8 and 45.4% of fully resistant strains), for erythromycin: 57.5 and 68.5%, for tetracycline: 43.2 and 42.6%, for trimethoprim-sulfamethoxazole: 47.5 and 50.9%. Minimal inhibitory concentrations (MICs) of various betalactams were determined against a representative sample of strains (n = 99). Amoxicillin, cefpodoxime and cefuroxime MICs remained low against numerous penicillin resistant strains, indicating that these three oral antibiotics (in combination with clavulanate for amoxicillin) have a useful potential for the treatment of acute otitis media when risk factors for pneumococcal penicillin-resistant infections are detected.
ISSN:0929-693X