9-Deoxopodophyllotoxin derivatives as anti-cancer agents

Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particular...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-08, Vol.9 (15), p.2131-2134
Main Authors: Subrahmanyam, Duvvuri, Renuka, B., Kumar, G.Sunil, Vandana, V., Deevi, Danvanthri S.
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
General aspects
Humans
Medical sciences
Pharmacology. Drug treatments
Podophyllotoxin - analogs & derivatives
Podophyllotoxin - pharmacology
Tumor Cells, Cultured
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Summary:Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particularly against ovarian, renal and lung cancer cell lines. Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised form podophyllotoxin via semi-synthesis. Most of these analogues showed good in vitro anti-cancer activity against human tumor cell lines.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00347-9