Biliary elimination of endogenous nortestosterone by pregnant cows

A temporal study of the biliary elimination of endogenous 19‐nortestosterone during two successive pregnancies was made in three cows with cannulated gall bladders. Bile samples were analysed for 17β‐19‐nortestosterone (β‐NT) and the 17α‐epimer (α‐NT) by using high resolution gas chromatography and...

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Bibliographic Details
Published in:Veterinary record 1998-09, Vol.143 (11), p.296-299
Main Authors: McEvoy, J. D. G., McVeigh, C. E., McCaughey, W. J., Hewitt, S. A.
Format: Article
Language:English
Subjects:
Animals
Biliary Tract - physiology
Cattle - physiology
Chromatography, Gas
Female
Labor, Obstetric
Nandrolone - analysis
Nandrolone - metabolism
Postpartum Period
Pregnancy
Pregnancy, Animal - physiology
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Summary:A temporal study of the biliary elimination of endogenous 19‐nortestosterone during two successive pregnancies was made in three cows with cannulated gall bladders. Bile samples were analysed for 17β‐19‐nortestosterone (β‐NT) and the 17α‐epimer (α‐NT) by using high resolution gas chromatography and mass spectroscopy. No β‐NT was detected in any of the samples analysed. However, α‐NT was detected from around 120 days of gestation in each of the cows. Peak concentrations were observed in the last week before calving and ranged from 9.5 to 36.7 ng/ml. After parturition, the concentrations of α‐NT declined rapidly and were undetectable by seven days after calving, and it was not detected again until after 120 days of gestation. The biliary concentrations of α‐NT detected subsequently were similar to those observed in cattle several weeks after an exogenous injection of the synthetic ester β‐NT phenylpropionate.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.143.11.296