The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma

Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to n...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 1999-08, Vol.143 (1), p.29-35
Main Authors: Leonardos, L, Butler, L.M, Hewett, P.J, Zalewski, P.D, Cowled, P.A
Format: Article
Language:English
Subjects:
Adenoma - enzymology
Adenoma - pathology
Adult
Aged
Aged, 80 and over
Amino Acid Chloromethyl Ketones - pharmacology
Apoptosis
Biological and medical sciences
Carcinoma - enzymology
Carcinoma - pathology
Caspase 3
Caspase Inhibitors
Caspases - metabolism
Colorectal carcinoma
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - pathology
Coumarins
Cysteine Proteinase Inhibitors - pharmacology
Enzyme Precursors - antagonists & inhibitors
Enzyme Precursors - metabolism
Female
Fluorescence
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intestinal Mucosa - enzymology
Jurkat Cells - enzymology
Male
Medical sciences
Middle Aged
Oligopeptides
Protease
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to normal mucosa ( P
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(99)00176-7