In vivo conversion of linoleic acid to arachidonic acid in human adults

Human adults are shown to be capable of conversion of linoleic acid (LA, 18:2 n-6) to arachidonic acid (AA, 20:4 n-6) in vivo. It is confirmed that they can also convert alpha-linolenic acid (LNA, 18:3 n-3) to eicosapentaenoic acid (EPA, 20:5 n-3) and to docosahexaenoic acid (DHA, 22:6 n-3) in vivo....

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1999-05, Vol.60 (5), p.407-410
Main Authors: Salem, N., Pawlosky, R., Wegher, B., Hibbeln, J.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Arachidonic Acid - blood
Biological and medical sciences
Dietary Fats - administration & dosage
Dietary Fats - blood
Fundamental and applied biological sciences. Psychology
Gas Chromatography-Mass Spectrometry
Humans
Linoleic Acid - administration & dosage
Linoleic Acid - blood
Lipids. Glycolipids
Metabolisms and neurohumoral controls
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Human adults are shown to be capable of conversion of linoleic acid (LA, 18:2 n-6) to arachidonic acid (AA, 20:4 n-6) in vivo. It is confirmed that they can also convert alpha-linolenic acid (LNA, 18:3 n-3) to eicosapentaenoic acid (EPA, 20:5 n-3) and to docosahexaenoic acid (DHA, 22:6 n-3) in vivo. The time course and the maximal response for these processes during the first week after a single dose of the 18-carbon precursor is described. A stable-isotope method in which the protons of the C17 and C18 carbons are substituted with deuterium atoms is used in order to provide for a safe method for the study of human metabolism. High sensitivity and selectivity of detection is assured with negative ion, gas chromatography/mass spectrometry analysis. It is clear that human adults on an ad lib diet carry out EFA metabolism in vivo.
ISSN:0952-3278
1532-2823
DOI:10.1016/S0952-3278(99)80021-0