Diagnostic value of connective tissue metabolites in Schistosoma mansoni related liver disease

Reliable non-invasive markers of hepatosplenic involvement in schistosomiasis are needed for determination of morbidity levels in endemic populations and for diagnosis and follow-up of affected individuals. Serum levels of connective tissue metabolites have been investigated as fibrosis markers in v...

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Bibliographic Details
Published in:Acta tropica 1999-07, Vol.73 (2), p.153-164
Main Authors: Kardorff, R., Mugashe, C., Gabone, R.M., Mahlert, C., Doehring, E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biomarkers
Connective Tissue - metabolism
Diagnosis
Diseases caused by trematodes
Endemic Diseases
Feces - parasitology
Female
Helminthic diseases
Humans
Infectious diseases
Laminin
Laminin - analysis
Liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - epidemiology
Liver Cirrhosis - metabolism
Liver Diseases, Parasitic - diagnosis
Liver Diseases, Parasitic - diagnostic imaging
Liver Diseases, Parasitic - epidemiology
Liver Diseases, Parasitic - metabolism
Male
Medical sciences
Morbidity
Parasite Egg Count
Parasitic diseases
Peptide Fragments - analysis
Portal Vein - pathology
Procollagen
Procollagen - analysis
Rural Population
Schistosomiases
Schistosomiasis mansoni
Schistosomiasis mansoni - diagnosis
Schistosomiasis mansoni - diagnostic imaging
Schistosomiasis mansoni - epidemiology
Schistosomiasis mansoni - metabolism
Splenomegaly
Tanzania
Tanzania - epidemiology
Tropical medicine
Ultrasonography
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Summary:Reliable non-invasive markers of hepatosplenic involvement in schistosomiasis are needed for determination of morbidity levels in endemic populations and for diagnosis and follow-up of affected individuals. Serum levels of connective tissue metabolites have been investigated as fibrosis markers in various hepatic disorders, but their accuracy in the detection of hepatosplenic schistosomiasis under endemic conditions has not been fully elucidated. 206 adult inhabitants of a Tanzanian village highly endemic for schistosomiasis mansoni (prevalence 88%) underwent clinical, parasitological and sonographic work-up; sera were tested for aminoterminal procollagen III-peptide (PIIIP), carboxyterminal procollagen IV peptide (NC1) and laminin. Connective tissue marker levels did not correlate with the presence or intensity of infection. NC1 levels were significantly correlated with periportal liver fibrosis ( P
ISSN:0001-706X
1873-6254
DOI:10.1016/S0001-706X(99)00022-4