Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family

• Published in: Cellular signalling 1998-10, Vol.10 (9), p.619-628
• Main Authors: de Groot, Rolf P., Coffer, Paul J., Koenderman, Leo
• Format: Article
• Language: English
• Subjects: Animals; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Cell Differentiation - physiology; Cell Division - physiology; Cell Survival - physiology; DNA-Binding Proteins - metabolism; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Humans; Interleukin-3 - metabolism; Interleukin-5 - metabolism; Milk Proteins; Phosphatidylinositol 3-Kinases - metabolism; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Receptors, Interleukin-3 - metabolism; Signal Transduction - physiology; STAT5 Transcription Factor; Trans-Activators - metabolism
• ISSN: 0898-6568; 1873-3913
• DOI: 10.1016/S0898-6568(98)00023-0

The receptors for the Il-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific α chain and a common β chain (βc). Binding of IL-3/IL-5/GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways, including the Ras-Raf-ERK, the JAK/STAT, the phosphatidylinositol 3-kinase PKB, and the JNK/SAPK and p38 signalling pathways. This review focuses on recent advancements in understanding how these different signalling pathways are activated by IL-3/IL-5/GM-CSF receptors, and how the individual pathways contribute to the pleiotropic effects of IL-3/IL-5/GM-CSF on their target cells, including proliferation, differentiation, survival, and effector functions.