Primary Hepatic Amyloidosis Well Delineated by Tc-99m DTPA Galactosyl HSA Liver SPECT

Tc-99m GSA is a hepatic tracer that specifically binds to the asialoglycoprotein receptors on the membrane of hepatocytes. Decreased hepatic uptake indicates liver dysfunction. Heterogeneous uptake of Tc-99m GSA in the liver was observed in a patient with primary hepatic amyloidosis, although the he...

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Bibliographic Details
Published in:Clinical nuclear medicine 1999-04, Vol.24 (4), p.271-273
Main Authors: KOIZUMI, KIYOSHI, MONZAWA, SHUICHI, SHINDO, CHIKARA, HOSAKA, MASARU
Format: Article
Language:English
Subjects:
Aged
Amyloidosis
Amyloidosis - diagnostic imaging
Biological and medical sciences
Humans
Liver - diagnostic imaging
Liver Diseases - diagnostic imaging
Male
Medical sciences
Metabolic diseases
Other metabolic disorders
Radiopharmaceuticals
Technetium Tc 99m Aggregated Albumin
Technetium Tc 99m Pentetate
Tomography, Emission-Computed, Single-Photon
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Description
Summary:Tc-99m GSA is a hepatic tracer that specifically binds to the asialoglycoprotein receptors on the membrane of hepatocytes. Decreased hepatic uptake indicates liver dysfunction. Heterogeneous uptake of Tc-99m GSA in the liver was observed in a patient with primary hepatic amyloidosis, although the hepatic uptake of Tc-99m HMDP was rather homogeneous. SPECT imaging showed that the distribution of decreased uptake was in an area in the liver analogous to that of a low-density area seen on CT scan. Tc-99m GSA SPECT might be useful to determine the spared area in the liver involved with amyloid deposition.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199904000-00012