Quantitative angiographic analysis of stent restenosis in the scripps coronary radiation to inhibit intimal proliferation post stenting (SCRIPPS) trial

To identify luminal dimension changes occurring within the stent alone and within the stent + margin segment, we reviewed the quantitative angiographic results obtained from the Scripps Coronary Radiation to Inhibit Proliferation Post Stenting (SCRIPPS) trial, a prospective randomized trial assessin...

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Bibliographic Details
Published in:The American journal of cardiology 1999-08, Vol.84 (4), p.410-414
Main Authors: Lansky, Alexandra J, Popma, Jeffrey J, Massullo, Vincent, Jani, Shirish, Russo, Robert J, Schatz, Richard A, Steuterman, Stephen, Guarneri, Ermina M, Wu, Hongsheng, Mehran, Roxana, Mintz, Gary S, Leon, Martin B, Teirstein, Paul S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brachytherapy - methods
Cardiovascular disease
Cardiovascular system
Cell Division - radiation effects
Cineangiography
Coronary Angiography - methods
Coronary Disease - diagnosis
Coronary Disease - radiotherapy
Coronary Disease - surgery
Coronary Vessels - diagnostic imaging
Coronary Vessels - pathology
Coronary Vessels - radiation effects
Follow-Up Studies
Graft Occlusion, Vascular - diagnosis
Graft Occlusion, Vascular - etiology
Graft Occlusion, Vascular - radiotherapy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Iridium Radioisotopes - therapeutic use
Medical research
Medical sciences
Prospective Studies
Prosthesis Failure
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Stents
Treatment Outcome
Tunica Intima - diagnostic imaging
Tunica Intima - pathology
Tunica Intima - radiation effects
Ultrasonography, Interventional
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Summary:To identify luminal dimension changes occurring within the stent alone and within the stent + margin segment, we reviewed the quantitative angiographic results obtained from the Scripps Coronary Radiation to Inhibit Proliferation Post Stenting (SCRIPPS) trial, a prospective randomized trial assessing the effect of iridium-192 (Ir-192) on the prevention of stent restenosis. Fifty-five patients were randomly assigned to receive Ir-192 or placebo sources after successful intervention. Procedural and 6-month follow-up cineangiograms were quantitatively reviewed in 52 patients to identify changes within the stent and the stent + margin segment. The percent diameter stenosis was lower within the stent than within the stent + margin segment after the procedure (6 ± 22% vs 21± 15%, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00325-2