Tl-201 and Ga-67 Scintigraphy in Non-Hodgkin's Lymphoma

Ga-67 scintigraphy is routinely used to stage and monitor non-Hodgkin's lymphoma (NHL). It is highly sensitive in high-grade NHL but less so in intermediate- and low-grade NHL. Several studies have reported the use of Tl-201 in the low and intermediate grades of NHL and found it superior in low...

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Bibliographic Details
Published in:Clinical nuclear medicine 1999-04, Vol.24 (4), p.239-242
Main Authors: MANSBERG, ROBERT, WADHWA, SURJIT S, MANSBERG, VICTOR
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Gallium Radioisotopes
Humans
Lymphoma, Non-Hodgkin - diagnostic imaging
Lymphoma, Non-Hodgkin - pathology
Male
Middle Aged
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Staging
Observer Variation
Prospective Studies
Radionuclide Imaging
Radiopharmaceuticals
Sensitivity and Specificity
Single-Blind Method
Thallium Radioisotopes
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Summary:Ga-67 scintigraphy is routinely used to stage and monitor non-Hodgkin's lymphoma (NHL). It is highly sensitive in high-grade NHL but less so in intermediate- and low-grade NHL. Several studies have reported the use of Tl-201 in the low and intermediate grades of NHL and found it superior in low-grade NHL. In this study, the authors evaluated the utility of combined Ga-67 and Tl-201 scintigraphy in low, intermediate, and unusual types of NHL. Combined Tl-201 and Ga-67 scintigraphy were done in 33 patients (18 women, 15 men; age range, 21-91 years; mean age, 56 years). Tl-201 and Ga-67 had similar overall patient sensitivity in the 33 patients studied. However, the use of both agents increased the over-all patient sensitivity from 67% (for Ga-67 only) to 82% and improved the overall site detection from 59 positive sites with Ga-67 to 81 abnormal sites with both Tl-201 and Ga-67. The combined use of Tl-201 and Ga-67 scintigraphy in low- and intermediate-grade NHL resulted in increased disease and site detection and is beneficial for clinical follow-up.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199904000-00004