Eosinophilia and Positive Skin Tests Predict Cardiovascular Mortality in a General Population Sample Followed for 30 Years

The authors investigated whether two objective allergy markers, peripheral blood eosinophilia and skin tests for common aeroallergens, were associated with cardiovascular death. Of 5, 382 subjects in the Vlagtwedde-Vlaardingen Study (the Netherlands) with data on allergy markers in 1965–1972, 507 su...

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Bibliographic Details
Published in:American journal of epidemiology 1999-09, Vol.150 (5), p.482-491
Main Authors: Hospers, Jeannette J., Rijcken, Bert, Schouten, Jan P., Postma, Dirkje S., Weiss, Scott T.
Format: Article
Language:English
Subjects:
allergens
Asthma - epidemiology
Biological and medical sciences
Biomarkers
Blood and lymphatic vessels
Body Mass Index
Cardiology. Vascular system
cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
cohort studies
eosinophila
Eosinophilia
Female
Follow-Up Studies
Humans
Hypersensitivity - epidemiology
Male
Medical sciences
Miscellaneous
mortality
population
Proportional Hazards Models
Respiratory Function Tests
Risk Factors
Skin Tests
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Summary:The authors investigated whether two objective allergy markers, peripheral blood eosinophilia and skin tests for common aeroallergens, were associated with cardiovascular death. Of 5, 382 subjects in the Vlagtwedde-Vlaardingen Study (the Netherlands) with data on allergy markers in 1965–1972, 507 subjects died from cardiovascular disease during 30 years of follow-up. Subjects with eosinophilia had an increased risk of cardiovascular death (relative risk (RR) = 1.7; 95% confidence interval (CI): 1.4, 2.2), including ischemic heart disease death (RR = 1.6; 95% CI: 1.2, 2.2) and cerebrovascular death (RR = 2.3; 95% CI: 1.4, 3.8), independent of major risk factors. This association was limited to subjects with a percentage of the predicted forced expiratory volume in 1 second (FEV1 % predicted) of
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a010037