Expression of endothelin-1 in macrophages and mast cells in hyperplastic human tonsils

In situ hybridization and immunohistochemical examinations of surgically resected specimens of human hyperplastic tonsils showed that macrophages in the germinal center and mast cells in the parafollicular and interfollicular areas expressed the transcript and protein of endothelin (ET)-1, but not E...

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Bibliographic Details
Published in:FEBS letters 1999-09, Vol.457 (3), p.381-384
Main Authors: Li, Zhiyuan, Niwa, Yasuharu, Rokutan, Kazuhito, Nakaya, Yutaka
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal - metabolism
Endothelin-1
Endothelin-1 - genetics
Endothelin-1 - metabolism
Female
Human tonsil
Humans
Hyperplasia - metabolism
Hyperplasia - pathology
Immunohistochemistry
In situ hybridization
Macrophage
Macrophages - chemistry
Macrophages - metabolism
Male
Mast cell
Mast Cells - chemistry
Mast Cells - metabolism
Middle Aged
Nitric Oxide Synthase - immunology
Nitric Oxide Synthase Type II
Palatine Tonsil - metabolism
Palatine Tonsil - pathology
Reference Values
RNA, Messenger - metabolism
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Summary:In situ hybridization and immunohistochemical examinations of surgically resected specimens of human hyperplastic tonsils showed that macrophages in the germinal center and mast cells in the parafollicular and interfollicular areas expressed the transcript and protein of endothelin (ET)-1, but not ET-2 and ET-3. The macrophages appeared to be activated, since they possessed significant amounts of inducible nitric oxide synthase. None of these expressions was observed in normal tonsil. Our results suggest that the over-production of ET-1 by macrophages and mast cells may be involved in the pathogenesis of hyperplastic tonsils.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)01085-6