Yolk sac tumor of the stomach with an adenocarcinomatous component: A case report with immunohistochemical analysis

A 56‐year‐old male treated for a gastric yolk sac tumor with an adenocarcinomatous component is described. A mixed area of reticular and glandular neoplastic components was morphologically identified in this tumor. Immunohistochemically, the yolk sac tumor expressed alpha‐fetoprotein (AFP), placenta...

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Bibliographic Details
Published in:Pathology international 1999-06, Vol.49 (6), p.557-562
Main Authors: Suzuki, Takashi, Kimura, Noriko, Shizawa, Soichiro, Yabuki, Noritaka, Yamaki, Toshihiko, Sasano, Hironobu, Nagura, Hiroshi
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - chemistry
Adenocarcinoma - pathology
Adenocarcinoma - surgery
alpha-fetoprotein
Biomarkers, Tumor - analysis
Endodermal Sinus Tumor - chemistry
Endodermal Sinus Tumor - pathology
Endodermal Sinus Tumor - surgery
Humans
Immunoenzyme Techniques
immunohistochemistry
Male
Middle Aged
Neoplasms, Multiple Primary - chemistry
Neoplasms, Multiple Primary - pathology
placental alkaline phosphatase
stomach
Stomach Neoplasms - chemistry
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
yolk sac tumor
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Summary:A 56‐year‐old male treated for a gastric yolk sac tumor with an adenocarcinomatous component is described. A mixed area of reticular and glandular neoplastic components was morphologically identified in this tumor. Immunohistochemically, the yolk sac tumor expressed alpha‐fetoprotein (AFP), placental alkaline phosphatase (PLAP), and cytokeratin, but was negative for carcinoembryonic antigen (CEA). The adenocarcinoma was positive for CEA and cytokeratin, partially positive for PLAP, and negative for AFP. In the mixed area, the tumor cells were positive for cytokeratin, weakly expressed AFP and PLAP, and sporadically stained for CEA both in the reticular and glandular components. This area was identified as a transitional area of the yolk sac tumor and adenocarcinoma. These findings demonstrate that the yolk sac and adenocarcinomatous components are closely related. It also suggests that the tumor arose from multipotential neoplastic mucosal epithelial cells with both yolk sac and gastric mucosal phenotypes.
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.1999.00907.x