CHRONIC INTERMITTENT IMMOBILIZATION OF MALE RATS THROUGHOUT SEXUAL DEVELOPMENT: A STRESS PROTOCOL

A stress protocol - 6 h of daily immobilization - was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocor...

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Bibliographic Details
Published in:Experimental physiology 1998-09, Vol.83 (5), p.701-704
Main Authors: Almeida, S. A., Anselmo-Franci, J. A., Silva, A. A. Rosa e, Carvalho, T. L. Lamano
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Animals
Corticosterone - blood
Growth
Immobilization
Luteinizing Hormone - blood
Male
Rapid Communication
Rats
Rats, Wistar
Sex
Space life sciences
Stress, Physiological - blood
Stress, Physiological - etiology
Stress, Physiological - physiopathology
Testosterone - blood
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Summary:A stress protocol - 6 h of daily immobilization - was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, caused a decrease in plasma luteinizing hormone (LH) after 15 and 60 days of immobilization and in plasma testosterone after 60 days, but produced an opposite androgenic response in pubertal animals (15 days of immobilization). A presumed sympathetic over-stimulation is suggested to account for increased testosterone levels in pubertal stressed rats.
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.1998.sp004151