Boranophosphate Nucleic Acids - A Versatile DNA Backbone

Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form h...

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Bibliographic Details
Published in:Nucleosides & nucleotides 1999-06, Vol.18 (6-7), p.1379-1380
Main Authors: Rait, Vladimir, Sergueev, Dmitri, Summers, Jack, He, Kaizhang, Huang, Faqing, Krzyzanowska, Bozenna, Shaw, Barbara Ramsay
Format: Article
Language:English
Subjects:
Boron Compounds - chemistry
Crystallography, X-Ray
DNA - chemistry
Nucleic Acid Conformation
Nucleic Acids - chemistry
Organophosphorus Compounds - chemistry
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Summary:Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be synthesized enzymatically and form stable duplexes with DNA. Fully boronated, non-stereoregular oligothymidylates, synthesized chemically, form hybrids with poly(A) that have lower melting points than oligothymidylate:poly(A), yet they nevertheless can support the RNase H mediated cleavage of RNA.
ISSN:0732-8311
DOI:10.1080/07328319908044721