Residual dipolar coupling of the Cr/PCr methyl resonance in resting human medial gastrocnemius muscle

This paper presents a detailed analysis of the TE dependence of the creatine methyl proton signal at 3.02 ppm, resulting from a symmetric PRESS sequence applied to the resting human gastrocnemius muscle. The analysis shows that a two‐component decay of the central peak of the dipolar‐coupled‐methyl...

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Bibliographic Details
Published in:Magnetic resonance in medicine 1999-09, Vol.42 (3), p.421-424
Main Authors: Hanstock, C.C., Thompson, R.B., Trump, M.E., Gheorghiu, D., Hochachka, P.W., Allen, P.S.
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Cr/PCr methyl resonance
Creatine - metabolism
gastrocnemius
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Spectroscopy
Medical sciences
Models, Statistical
Muscle, Skeletal - metabolism
Osteoarticular system. Muscles
Phosphocreatine - metabolism
Protons
Radiodiagnosis. Nmr imagery. Nmr spectrometry
residual dipolar coupling
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Summary:This paper presents a detailed analysis of the TE dependence of the creatine methyl proton signal at 3.02 ppm, resulting from a symmetric PRESS sequence applied to the resting human gastrocnemius muscle. The analysis shows that a two‐component decay of the central peak of the dipolar‐coupled‐methyl triplet should be interpreted as the superposition of a rapid (≈34 msec) dipolar dephasing and a less rapid (≈162 msec) transverse relaxation. These data do not support a two‐pool hypothesis for TE dependence of this signal. Magn Reson Med 42:421–424, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/(SICI)1522-2594(199909)42:3<421::AID-MRM2>3.0.CO;2-6