Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our pla...

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Bibliographic Details
Published in:Vaccine 1998-11, Vol.16 (19), p.1836-1841
Main Authors: Bagarazzi, Mark L., Boyer, Jean D., Ugen, Kenneth E., Ali Javadian, M., Chattergoon, Michael, Shah, Ami, Bennett, Mosi, Ciccarelli, Richard, Carrano, Richard, Coney, Leslie, Weiner, David B.
Format: Article
Language:English
Subjects:
AIDS Vaccines - adverse effects
AIDS Vaccines - immunology
AIDS Vaccines - therapeutic use
AIDS/HIV
Animals
antibody
Biological and medical sciences
CTL
Disease Models, Animal
DNA, Viral - genetics
DNA, Viral - immunology
Female
flow cytometry
Fundamental and applied biological sciences. Psychology
gene
HIV Antibodies - blood
HIV Infections - blood
HIV Infections - prevention & control
HIV-1 - genetics
HIV-1 - immunology
immunization
lymphocyte proliferation
Lymphocyte Subsets - immunology
Male
Microbiology
mucosal
Pan troglodytes
plasmid
Pregnancy
primate
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, DNA - adverse effects
Vaccines, DNA - immunology
Vaccines, DNA - therapeutic use
Virology
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Summary:A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(98)00178-9