The LXRs: a new class of oxysterol receptors

The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the functi...

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Bibliographic Details
Published in:Current opinion in genetics & development 1998-10, Vol.8 (5), p.571-575
Main Authors: Peet, Daniel J, Janowski, Bethany A, Mangelsdorf, David J
Format: Article
Language:English
Subjects:
Animals
Cholesterol, Dietary
Dimerization
DNA-Binding Proteins
Humans
Liver X Receptors
Mice
Mice, Knockout
Orphan Nuclear Receptors
Receptors, Cytoplasmic and Nuclear - chemistry
Receptors, Cytoplasmic and Nuclear - deficiency
Receptors, Cytoplasmic and Nuclear - metabolism
Receptors, Retinoic Acid - chemistry
Receptors, Retinoic Acid - metabolism
Retinoid X Receptors
Sterols - metabolism
Transcription Factors - chemistry
Transcription Factors - metabolism
Transcription, Genetic
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Summary:The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(98)80013-0