Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet

To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and d...

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Bibliographic Details
Published in:American journal of hypertension 1999-08, Vol.12 (8), p.826-829
Main Authors: Antic, Vladan, Tempini, Aldo, Montani, Jean-Pierre
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Cardiology. Vascular system
Dietary Fats - adverse effects
Energy Intake - physiology
Experimental diseases
Glomerular Filtration Rate - physiology
Heart Rate - physiology
Hemodynamics - physiology
high-fat diet
hypertension
Kidney - physiology
Kidney Function Tests
Male
Medical sciences
Obesity
Obesity - physiopathology
Rabbits
Sodium - blood
Sodium - metabolism
Telemetry
Time Factors
Water-Electrolyte Balance - physiology
Weight Gain - physiology
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Summary:To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and daily urine collection. High-fat diet induced a progressive increase in body weight (+47%) and a rapid rise in mean arterial pressure, heart rate, and glomerular filtration rate that stabilized, respectively, at 14%, 31% and 68% greater than control values. Time-course analysis of changes in blood pressure may reveal two components of obesity-induced hypertension, an early phase related to HFD itself and a later phase related to weight gain.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(98)00231-3