Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis

Several epidemiological studies have reported an association between complications of pregnancy and delivery and schizophrenia, but none have had sufficient power to examine specific complications that, individually, are of low prevalence. We, therefore, performed an individual patient meta-analysis...

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Bibliographic Details
Published in:Schizophrenia bulletin 1999-01, Vol.25 (3), p.413-423
Main Authors: Geddes, John R., Verdoux, Hélène, Takei, Nori, Lawrie, Stephen M., Bovet, Pierre, Eagles, John M., Heun, Reinhard, McCreadie, Robin G., McNeil, Thomas F., O'Callaghan, Eadbhard, Stöber, Gerald, Willinger, Ulrike, Murray, Robin M.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Birth
Case-Control Studies
Extraction, Obstetrical - adverse effects
Extraction, Obstetrical - statistics & numerical data
Female
Human
Humans
Labor (Childbirth)
Male
Medical sciences
Obstetric Labor, Premature - complications
Obstetric Labor, Premature - epidemiology
Obstetrical Complications
Pregnancy
Pregnancy Complications - epidemiology
Prenatal Development
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Research Design
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - etiology
Sequelae
Statistics as Topic
Systematic review
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Summary:Several epidemiological studies have reported an association between complications of pregnancy and delivery and schizophrenia, but none have had sufficient power to examine specific complications that, individually, are of low prevalence. We, therefore, performed an individual patient meta-analysis using the raw data from case control studies that used the Lewis-Murray scale. Data were obtained from 12 studies on 700 schizophrenia subjects and 835 controls. There were significant associations between schizophrenia and premature rupture of membranes, gestational age shorter than 37 weeks, and use of resuscitation or incubator. There were associations of borderline significance between schizophrenia and birthweight lower than 2,500 g and forceps delivery. There was no significant interaction between these complications and sex. We conclude that some abnormalities of pregnancy and delivery may be associated with development of schizophrenia. The pathophysiology may involve hypoxia and so future studies should focus on the accurate measurement of this exposure.
ISSN:0586-7614
1745-1701
DOI:10.1093/oxfordjournals.schbul.a033389