Chemokine Receptor Polymorphisms and Human Immunodeficiency Virus Disease Progression

• Published in: The Journal of infectious diseases 1999-10, Vol.180 (4), p.1096-1105
• Main Authors: Easterbrook, Philippa J., Rostron, Tim, Ives, Natalie, Troop, Maxine, Gazzard, Brian G., Rowland-Jones, Sarah L.
• Format: Article
• Language: English
• Subjects: AIDS; AIDS/HIV; Alleles; Biological and medical sciences; Bisexuality; Case-Control Studies; CCR2b protein; CCR5 protein; Confidence Intervals; Disease Progression; DNA Primers; Epidemiology; Fundamental and applied biological sciences. Psychology; Genetic mutation; Genotype; Genotypes; HIV; HIV 1; HIV Antibodies - blood; HIV infections; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - physiopathology; Homosexuality, Male; Human immunodeficiency virus 1; Human viral diseases; Humans; Infections; Infectious diseases; Major Articles; Male; Medical sciences; Microbiology; Nucleotides; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Receptors, CCR2; Receptors, CCR5 - genetics; Receptors, Chemokine - genetics; Receptors, Cytokine - genetics; SDF-1 protein; Time Factors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/314997

The role of polymorphisms in genes encoding chemokines and their receptors (CCR2B, SDF-1, and the promoter region of CCR5) in human immunodeficiency virus (HIV) disease progression was studied in 132 white HIV type 1 (HlV-l)-infected participants from a United Kingdom cohort study. Genotyping was done by use of amplification refractory mutation system-polymerase chain reaction with sequence-specific primers, and Cox proportional hazards models were used to examine the impact of polymorphisms on time to a CD4 cell count