Facilitation of chromatin dynamics by SARs

Metaphase chromosome condensation is a dynamic process that must utilize cis elements to form and maintain the final structure. Likewise, cis elements must regulate the accessibility of chromatin domains to protein machines involved in processes such as transcription. Scaffold associated regions app...

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Bibliographic Details
Published in:Current opinion in genetics & development 1998-10, Vol.8 (5), p.519-525
Main Authors: Hart, Craig M, Laemmli, Ulrich K
Format: Article
Language:English
Subjects:
Animals
Cell Nucleus - ultrastructure
Chromatin - genetics
Chromatin - physiology
DNA - chemistry
DNA - genetics
Gene Expression Regulation
Metaphase
Mitosis
Nucleic Acid Conformation
Transcription, Genetic
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Summary:Metaphase chromosome condensation is a dynamic process that must utilize cis elements to form and maintain the final structure. Likewise, cis elements must regulate the accessibility of chromatin domains to protein machines involved in processes such as transcription. Scaffold associated regions appear to play important roles in both of these dynamic processes.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(98)80005-1