Trisomy 6 as a Primary Karyotypic Aberration in Hematologic Disorders

We identified seven patients with hematologic disorders and trisomy 6 as the sole karyotypic aberration in bone marrow aspirates or unstimulated peripheral blood. Five patients were male and two were female; all were adults with ages ranging from 22 to 74 years. Three of the seven patients presented...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1998-10, Vol.106 (2), p.152-155
Main Authors: Mohamed, Anwar N., Varterasian, Mary L., Dobin, Sheila M., McConnell, Thomas S., Wolman, Sandra R., Rankin, Cathryn, Willman, Cheryl L., Head, David R., Slovak, Marilyn L.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Bone Marrow - pathology
Chromosomes, Human, Pair 6
Female
Hematologic and hematopoietic diseases
Hematologic Diseases - genetics
Hematologic Diseases - pathology
Humans
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Preleukemia - genetics
Preleukemia - pathology
Trisomy
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Summary:We identified seven patients with hematologic disorders and trisomy 6 as the sole karyotypic aberration in bone marrow aspirates or unstimulated peripheral blood. Five patients were male and two were female; all were adults with ages ranging from 22 to 74 years. Three of the seven patients presented with manifestations of peripheral cytopenia. Their bone marrows were hypocellular with slight or no dysplastic changes and without an increase in blasts. One of these patients subsequently developed acute myeloid leukemia (AML-M1). The four remaining patients were initially diagnosed with AML—three consistent with French-American-British classification of M1 and M4 in the fourth patient. These results suggest that trisomy 6 is a nonrandom primary numerical anomaly of myeloid disorders. The association of cytopenia and hypoplastic bone marrow with trisomy 6 may constitute a new, distinctive variant among myelodysplastic syndromes.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(98)00057-0