Lymphocyte glutathione levels in acute leukemia

The current interest in the clinical significance of the glutathione estimation in leukemia is due to its widespread effect on the cell constituent and cell function of the hematopoietic system. It helps and protects the cells against free radicals and reactive oxygen products. The present study was...

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Bibliographic Details
Published in:Clinica chimica acta 1999-07, Vol.285 (1), p.85-89
Main Authors: Singh Ghalaut, Veena, Kharb, Simmi, Ghalaut, P.S, Rawal, Amit
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Acute myeloid leukemia
Adolescent
Adult
Biological and medical sciences
Female
Glutathione
Glutathione - blood
Hematology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemia, Myeloid, Acute - blood
Leukemia, Myeloid, Acute - drug therapy
Lymphocytes
Lymphocytes - metabolism
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
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Summary:The current interest in the clinical significance of the glutathione estimation in leukemia is due to its widespread effect on the cell constituent and cell function of the hematopoietic system. It helps and protects the cells against free radicals and reactive oxygen products. The present study was conducted to estimate glutathione levels in lymphocytes of 20 patients with acute leukemia before and after chemotherapy to observe the relation of glutathione level to response to chemotherapy. Twenty age and sex matched healthy volunteers served as control. In acute myeloid leukemia, the levels were almost double than that of controls ( P
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(99)00109-6