Serum interleukin 1 in ovarian cancer patients

Interleukin-1 (IL-1) is a multifunctional cytokine playing a central role in the immune response and displaying direct cytotoxic activity in vitro. Serum IL-1 alpha and beta levels were measured by enzyme linked immunosorbent assay (ELISA) in 75 ovarian cancer patients, 30 patients with benign ovari...

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Bibliographic Details
Published in:European journal of cancer (1990) 1998-05, Vol.34 (6), p.931-933
Main Authors: ZEISLER, H, TEMPFER, C, JOURA, E. A, SLIUTZ, G, KOELBL, H, WAGNER, O, KAINZ, C
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Interleukin-1 - blood
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - blood
Ovarian Neoplasms - blood
Retrospective Studies
Tumors
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Summary:Interleukin-1 (IL-1) is a multifunctional cytokine playing a central role in the immune response and displaying direct cytotoxic activity in vitro. Serum IL-1 alpha and beta levels were measured by enzyme linked immunosorbent assay (ELISA) in 75 ovarian cancer patients, 30 patients with benign ovarian cysts and 50 healthy controls. Both serum IL-1 alpha and IL-1 beta levels were more often elevated in ovarian cancer patients compared with healthy controls (chi-square test, P < 0.001 and P < 0.001, respectively). Mean serum IL-1 alpha and beta levels decreased significantly after surgical intervention (paired t-test, P = 0.0001 and P = 0.0002, respectively). No correlation with histopathological parameters and overall and disease-free survival was found. These preliminary results indicate that serum levels of IL-1 alpha and beta represent a host defence reaction rather than an autonomous tumour cell production.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(97)10107-1