Changes in Calcium Uptake Rate by Rat Cardiac Mitochondria during Postnatal Development

Ca2+uptake, transmembrane electrical potential (Δψm) and oxygen consumption were measured in isolated ventricular mitochondria of rats from 3 days to 5 months of age. Estimated values of ruthenium red-sensitive, succinate-supported maximal rate of Ca2+uptake (Vmax, expressed as nmol Ca2+/min/mg prot...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 1998-10, Vol.30 (10), p.2013-2023
Main Authors: Bassani, Rosana A., Fagian, Marcia M., Bassani, José W.M., Vercesi, Anibal E.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Animals, Newborn
Ca2+uniporter
Ca2+uptake
Calcium - metabolism
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology
Electrical potential
Heart - growth & development
Intracellular Membranes - physiology
Kinetics
Membrane Potentials
Mitochondria
Mitochondria, Heart - drug effects
Mitochondria, Heart - physiology
Ontogeny
Oxygen Consumption
Postnatal development
Rats
Rats, Wistar
Respiration
Ruthenium Red - pharmacology
Succinates - metabolism
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Summary:Ca2+uptake, transmembrane electrical potential (Δψm) and oxygen consumption were measured in isolated ventricular mitochondria of rats from 3 days to 5 months of age. Estimated values of ruthenium red-sensitive, succinate-supported maximal rate of Ca2+uptake (Vmax, expressed as nmol Ca2+/min/mg protein) were higher in neonates and gradually fell during postnatal development (from 435±24 at 3–6 days, to 156±10 in adults,P
ISSN:0022-2828
1095-8584
DOI:10.1006/jmcc.1998.0762