Ratio of branched chain amino acid to tyrosine after hepatectomy

The roles of branched chain amino acids (BCAAs) and the tyrosine (Tyr) profile after liver resection were investigated using an inexpensive enzymatic method that was recently developed to quantify their concentrations. The preoperative BCAAs-to-Tyr ratio (BTR) was significantly correlated with the p...

Full description

Saved in:
Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 1999-01, Vol.29 (8), p.825-827
Main Authors: Niguma, T, Yumura, M, Yamasita, Y, Maeda, K, Kimura, T, Yamamura, M, Kodani, J
Format: Article
Language:English
Subjects:
Amino Acids, Branched-Chain - administration & dosage
Amino Acids, Branched-Chain - metabolism
Gastrectomy
Hepatectomy
Humans
Liver Neoplasms - diet therapy
Liver Neoplasms - surgery
Statistics, Nonparametric
Stomach Neoplasms - diet therapy
Stomach Neoplasms - surgery
Tyrosine - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The roles of branched chain amino acids (BCAAs) and the tyrosine (Tyr) profile after liver resection were investigated using an inexpensive enzymatic method that was recently developed to quantify their concentrations. The preoperative BCAAs-to-Tyr ratio (BTR) was significantly correlated with the preoperative indocyanin green clearance ratio. The BTR decreased immediately after surgery in all patients, but it was significantly lower in those who had undergone major hepatectomies. After the infusion of BCAA-enriched amino acid solution, the BTR increased substantially, being significantly higher in patients who had not suffered an elevation in total bilirubin after liver resection. These findings indicate that this new enzymatic method to quantify the concentration of BCAAs and Tyr is useful to control the infusion of amino acids and to study the role of amino acid metabolization during the perioperative period.
ISSN:0941-1291
1436-2813
DOI:10.1007/bf02482339