Glomerulosclerosis in the remnant kidney rat is modulated by dietary α-tocopherol

Glomerulosclerosis and tubulointerstitial injury are characteristic features seen in the subtotal (5/6) nephrectomy remnant kidney model in the rat. Oxidative stress from renal mass reduction contributes to the glomerular and tubular injury. Previous studies have clearly demonstrated the prevention...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Society of Nephrology 1998-11, Vol.9 (11), p.2089-2095
Main Authors: SEUNGHOON HAHN, KUEMMERLE, N. B, CHAN, W, HISANO, S, SABORIO, P, KRIEG, R. J, CHAN, J. C. M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Creatinine - blood
Diet
Glomerulosclerosis, Focal Segmental - drug therapy
Glomerulosclerosis, Focal Segmental - metabolism
Glomerulosclerosis, Focal Segmental - pathology
Kidney - metabolism
Kidney - pathology
Male
Malondialdehyde - blood
Malondialdehyde - metabolism
Medical sciences
Nephrectomy
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
Transforming Growth Factor beta - genetics
Urinary system
Vitamin E - administration & dosage
Vitamin E - blood
Vitamin E - therapeutic use
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glomerulosclerosis and tubulointerstitial injury are characteristic features seen in the subtotal (5/6) nephrectomy remnant kidney model in the rat. Oxidative stress from renal mass reduction contributes to the glomerular and tubular injury. Previous studies have clearly demonstrated the prevention or inhibition of such injury by an antioxidant such as alpha-tocopherol. However, few data are available on the ability of alpha-tocopherol to modulate or arrest progression of the established disease. This study examines whether alpha-tocopherol modulates glomerulosclerosis and tubulointerstitial injury when it is given 2 wk after renal damage has been established. The findings indicate that alpha-tocopherol has the capacity to modulate both tubulointerstitial injury and glomerulosclerosis, lower the elevated expression of transforming growth factor-beta1, and reduce plasma and kidney malondialdehyde concentration, the end product of lipid peroxidation. The results support the potential utility of alpha-tocopherol in reversing established glomerulosclerosis and tubulointerstitial injury in a remnant kidney model.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.V9112089