A polymorphic microsatellite marker in the rat major histocompatibility complex class I gene, RT1.M4, and a new recombinant RT1 haplotype, r39

The class I gene RT1.M4 is located at the telomeric end of RT1, the rat major histocompatibility complex (MHC), within the RT1.M region, which was defined by the recombinant haplotype r38. Analysis of the RT1.M4 gene revealed an informative simple-sequence length polymorphism (SSLP) marker. Together...

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Bibliographic Details
Published in:Immunogenetics (New York) 1998-11, Vol.48 (6), p.420-421
Main Authors: Lambracht-Washington, D, Shisa, H, Butcher, G W, Fischer Lindahl, K
Format: Article
Language:English
Subjects:
Animals
Base Sequence
DNA Primers
Genes, MHC Class I
Genetic Markers
Haplotypes
histocompatibility locus RT1
Microsatellite Repeats
Molecular Sequence Data
Polymorphism, Genetic
r39 gene
Rats
Rats, Inbred Strains
Recombination, Genetic
RT1.M4 gene
simple-sequence length polymorphism
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Summary:The class I gene RT1.M4 is located at the telomeric end of RT1, the rat major histocompatibility complex (MHC), within the RT1.M region, which was defined by the recombinant haplotype r38. Analysis of the RT1.M4 gene revealed an informative simple-sequence length polymorphism (SSLP) marker. Together with previously described SSLP markers in the RT1 region, the M4 repeat might facilitate the screening of large panels of offspring for intra-MHC recombinants and the mapping of genetic traits within the MHC region.
ISSN:0093-7711
1432-1211
DOI:10.1007/s002510050455