Quantitative determination of the angiotensin-converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry

A simple, highly accurate and precise method for the quantitative measurement of the angiotensin‐converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The preparation of stable isotope labelle...

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Published in:Rapid communications in mass spectrometry 1998-01, Vol.12 (21), p.1591-1594
Main Authors: Leis, H. J., Fauler, G., Raspotnig, G., Windischhofer, W.
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme Inhibitors - blood
Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics
Chromatography, Gas
Humans
Indicators and Reagents
Lisinopril - blood
Lisinopril - pharmacokinetics
Mass Spectrometry
Reproducibility of Results
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container_issue 21
container_start_page 1591
container_title Rapid communications in mass spectrometry
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creator Leis, H. J.
Fauler, G.
Raspotnig, G.
Windischhofer, W.
description A simple, highly accurate and precise method for the quantitative measurement of the angiotensin‐converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The preparation of stable isotope labelled lisinopril for use as an internal standard is described. The method involves solid phase extraction on C18 sorbent and derivatization to the methyl diester–trifluoroacetamide derivatives. The detection limit was found to be 50 pg and a lower limit of quantification was reached down to 0.5 ng/mL plasma. © 1998 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/(SICI)1097-0231(19981115)12:21<1591::AID-RCM368>3.0.CO;2-C
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source Wiley-Blackwell Read & Publish Collection
subjects Angiotensin-Converting Enzyme Inhibitors - blood
Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics
Chromatography, Gas
Humans
Indicators and Reagents
Lisinopril - blood
Lisinopril - pharmacokinetics
Mass Spectrometry
Reproducibility of Results
title Quantitative determination of the angiotensin-converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry
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