Sequence and expression of DmMKLP1, a homolog of the human MKLP1 kinesin-like protein from Drosophila melanogaster

We have isolated the Drosophila gene DmMKLP1, which has a high similarity to members of the mitotic kinesin-like subfamily of kinesin proteins. DmMKLP1 has no known close relatives in the Drosophila genome and can therefore be assumed to be the ortholog of human MKLP1 and hamster CHOI kinesin-like p...

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Bibliographic Details
Published in:Development genes and evolution 1998-10, Vol.208 (8), p.474-476
Main Authors: Schmid, K J, Tautz, D
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Drosophila
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila Proteins
Gene Expression Regulation, Developmental
Humans
Insects
Microtubule-Associated Proteins - chemistry
Microtubule-Associated Proteins - genetics
Molecular Sequence Data
Nervous system
Open Reading Frames
Sequence Homology, Amino Acid
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Summary:We have isolated the Drosophila gene DmMKLP1, which has a high similarity to members of the mitotic kinesin-like subfamily of kinesin proteins. DmMKLP1 has no known close relatives in the Drosophila genome and can therefore be assumed to be the ortholog of human MKLP1 and hamster CHOI kinesin-like proteins. In situ hybridization reveals a homogeneous maternal expression in the early embryo and a terminally restricted expression pattern at blastoderm stage. Later, the expression becomes increasingly restricted to the developing central nervous system, where it remains expressed at least until the end of embryogenesis.
ISSN:0949-944X
1432-041X
DOI:10.1007/s004270050205