New Geodiamolides from the Sponge Cymbastela sp. Collected in Papua New Guinea

Geodiamolides J−P (11−17) and R (19), eight new cyclic depsipetides, have been isolated from the marine sponge Cymbastela sp. collected in Papua New Guinea. The serine residue in geodiamolides L−P (13−17) and R (19) has not been previously found in this family of compounds.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1137-1141
Main Authors: Coleman, John E, Van Soest, Rob, Andersen, Raymond J
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Animals
Biological and medical sciences
chemical composition
chemical structure
Chromatography, High Pressure Liquid
Cymbastela
depsipeptides
derivatives
General pharmacology
geodiamolides
Hydrolysis
Magnetic Resonance Spectroscopy
Marine
Mass Spectrometry
Medical sciences
natural products
New Guinea
Papua New Guinea
parazoa
peptides
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
Porifera - chemistry
serine
spectral analysis
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Description
Summary:Geodiamolides J−P (11−17) and R (19), eight new cyclic depsipetides, have been isolated from the marine sponge Cymbastela sp. collected in Papua New Guinea. The serine residue in geodiamolides L−P (13−17) and R (19) has not been previously found in this family of compounds.
ISSN:0163-3864
1520-6025
DOI:10.1021/np990155o