Significance of the Anti-E2 Response in Self-Limited and Chronic Hepatitis C Virus Infections in Chimpanzees and in Humans

To determine whether there was a correlation between the kinetics or frequency of antibody to mammalian-derived hepatitis C virus (HCV) second envelope protein (E2) and development of chronicity or self-limitation of HCV infections, serial sera were examined for anti-E2, anti-HCV with confirmation w...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-10, Vol.180 (4), p.987-991
Main Authors: Prince, Alfred M., Brotman, Betsy, Lee, Dong-Hun, Ren, Leigh, Moore, Bonnie S., Scheffel, James W.
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Antibodies
Antibody production
Antigens
Biological and medical sciences
Blood Transfusion
Chronic hepatitis
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
GB virus C
Glycoproteins
Hepacivirus
Hepacivirus - immunology
Hepatitis C Antibodies - blood
Hepatitis C virus
Hepatitis C, Chronic - immunology
Hepatitis C, Chronic - physiopathology
Human viral diseases
Humans
Immunobiology
Infections
Infectious diseases
Major Articles
Medical sciences
Pan troglodytes
Polymerase chain reaction
Prospective Studies
Reverse transcriptase polymerase chain reaction
Time Factors
Viral diseases
Viral Envelope Proteins - immunology
Viral hepatitis
Viruses
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Summary:To determine whether there was a correlation between the kinetics or frequency of antibody to mammalian-derived hepatitis C virus (HCV) second envelope protein (E2) and development of chronicity or self-limitation of HCV infections, serial sera were examined for anti-E2, anti-HCV with confirmation with Matrix 2.0 (Abbott Laboratories, Abbott Park, IL), and reverse transcriptase-polymerase chain reaction (RT-PCR) from 6 cases of self-limited infection and 6 cases of chronic infection in chimpanzees, and from 5 cases of self-limited infection and 3 cases of chronic infection in patients. Anti-E2 developed earlier, more frequently, and to higher titer in chimpanzees and patients who were developing chronic infection than in those with self-limited infections. Thus anti-E2 is unlikely to play a role in self-limitation of the infection. However, long-term persistence of anti-E2 correlates with chronic infection. There was little or no correlation between the timing of development of anti-E2 and anti-HCV.
ISSN:0022-1899
1537-6613
DOI:10.1086/314973