Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: evidence for positive natural selection

Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus. We investigated patterns of DNA sequence variation at Abpa within and between species of mice to test s...

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Bibliographic Details
Published in:Molecular biology and evolution 1999-09, Vol.16 (9), p.1192-1197
Main Authors: Karn, R C, Nachman, M W
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Androgen-Binding Protein - genetics
Animals
Base Sequence
Evolution, Molecular
Genetic Linkage
Genetic Variation
Mice - genetics
Molecular Sequence Data
Muridae - genetics
Phylogeny
Selection, Genetic
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Species Specificity
X Chromosome - genetics
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Summary:Previous work has shown that the gene for the alpha subunit of androgen-binding protein, Abpa, may be involved in premating isolation between different subspecies of the house mouse, Mus musculus. We investigated patterns of DNA sequence variation at Abpa within and between species of mice to test several predictions of a model of neutral molecular evolution. Intraspecific variation among 10 Mus musculus domesticus alleles was compared with divergence between M. m. domesticus and M. caroli for Abpa and two X-linked genes, Glra2 and Amg. No variation was observed at Abpa within M. m. domesticus. The ratio of polymorphism to divergence was significantly lower at Abpa than at Glra2 and Amg, despite the fact that all three genes experience similar rates of recombination. Interspecific comparisons among M. m. domesticus, Mus musculus musculus, Mus musculus castaneus, Mus spretus, Mus spicilegus, and Mus caroli revealed that the ratio of nonsynonymous substitutions to synonymous substitutions on a per-site basis (Ka/Ks) was generally greater than one. The combined observations of no variation at Abpa within M. m: domesticus and uniformly high Ka/Ks values between species suggest that positive directional selection has acted recently at this locus.
ISSN:0737-4038
1537-1719
DOI:10.1093/oxfordjournals.molbev.a026209